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Monitor Carefully (two)istradefylline will increase the degree or outcome of pazopanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pazopanib will raise the degree or effect of midazolam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. Coadministration of moderate CYP3A4 inhibitors with midazolam